Difluorocarbene for Dehydroxytrifluoromethylthiolation of Alcohols.
Jia-Jia LuoMin ZhangJin-Hong LinJi-Chang XiaoPublished in: The Journal of organic chemistry (2017)
Dehydroxytrifluoromethylthiolation of alcohols with a Ph3P+CF2CO2-/S8/F- system is described. Difluorocarbene generated from Ph3P+CF2CO2- would readily combine with elemental sulfur to furnish S═CF2. S═CF2 can be considered as a bifunctional intermediate, activating alcohol and providing scaffold for CF3S- formation, thus allowing for the convenient dehydroxytrifluoromethylthiolation of alcohols.
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