Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder.

Zeynep YilmazKatherine SchaumbergMatthew HalvorsenErica L GoodmanLeigh C BrosofJames J Crowleynull nullnull nullnull nullCarol A MathewsManuel MattheisenGerome BreenCynthia M BulikNadia MicaliStephanie C Zerwas

Published in: Psychological medicine (2022)

Compulsive exercise may have a transdiagnostic genetic etiology, and AN genetic risk may play a role in the presence of anxiety symptoms. Converging with prior twin literature, our results also suggest that some of the contribution of genetic risk may be sex-specific.

Keyphrases

obsessive compulsive disorder
sleep quality
anorexia nervosa
genome wide
copy number
deep brain stimulation
systematic review
high intensity
gene expression
depressive symptoms