Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis.
Sujuan LiWeili WangLisha LinLian YangYing CaiXingzhi YangTaocui ZhangChuang XiaoHui YanNa GaoJinhua ZhaoPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
The study firstly report that the fucosylated glycosaminoglycan oligosaccharide has antiplatelet activity by binding to thrombin exosite II, and demonstrates that thrombin exosite II plays an important role in the simultaneous activation of PAR1 and PAR4, which may be a potential antithrombotic target for effective treatment of arterial thrombosis.