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Distance-dependent inhibition of translation initiation by downstream out-of-frame AUGs is consistent with a Brownian ratchet process of ribosome scanning.

Ke LiJinhui KongShuo ZhangTong ZhaoWenfeng Qian
Published in: Genome biology (2022)
Collectively, our findings uncover the basic process by which eukaryotic ribosomes scan for initiation codons, and how this process could shape eukaryotic genome evolution.
Keyphrases
  • computed tomography
  • gene expression
  • magnetic resonance
  • mass spectrometry
  • quality control