Harnessing Inorganic Nanoparticles to Direct Macrophage Polarization for Skeletal Muscle Regeneration.
Francesca CorsiFelicia CarotenutoPaolo Di NardoLaura TeodoriPublished in: Nanomaterials (Basel, Switzerland) (2020)
Modulation of macrophage plasticity is emerging as a successful strategy in tissue engineering (TE) to control the immune response elicited by the implanted material. Indeed, one major determinant of success in regenerating tissues and organs is to achieve the correct balance between immune pro-inflammatory and pro-resolution players. In recent years, nanoparticle-mediated macrophage polarization towards the pro- or anti-inflammatory subtypes is gaining increasing interest in the biomedical field. In TE, despite significant progress in the use of nanomaterials, the full potential of nanoparticles as effective immunomodulators has not yet been completely realized. This work discusses the contribution that nanotechnology gives to TE applications, helping native or synthetic scaffolds to direct macrophage polarization; here, three bioactive metallic and ceramic nanoparticles (gold, titanium oxide, and cerium oxide nanoparticles) are proposed as potential valuable tools to trigger skeletal muscle regeneration.
Keyphrases
- tissue engineering
- oxide nanoparticles
- skeletal muscle
- anti inflammatory
- immune response
- stem cells
- insulin resistance
- adipose tissue
- human health
- gene expression
- type diabetes
- wound healing
- big data
- metabolic syndrome
- toll like receptor
- silver nanoparticles
- water soluble
- inflammatory response
- perovskite solar cells
- iron oxide