Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review.
Ricardo A Torres-GuzmanFrancisco R AvilaKarla C MaitaJohn P GarciaGioacchino D De SarioSahar BornaAbdullah S EldalyAlfredo Quinones-HinojosaAbba C ZubairOlivia A HoAntonio Jorge FortePublished in: Journal of clinical medicine (2023)
This systematic review examined BMP and MSC synergy in biomaterial scaffolds or alone. BMP therapy and mesenchymal stem cells in calvarial defects, alone, or with a scaffold regenerated bone. This method treats skull defects in clinical trials. The best scaffold material, therapeutic dosage, administration method, and long-term side effects need further study.