Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer.
Fen MaSeiji AraiKeshan WangCarla CalaguaAmanda R YuanLarysa PolubenZhongkai GuJoshua W RussoDavid J EinsteinHuihui YeMeng Xiao HeYu LiuEliezer Van AllenAdam G SowalskyManoj K BhasinXin YuanSteven P BalkPublished in: Cancer research (2022)
This work provides fundamental insights into Wnt signaling and prostate cancer cell biology and indicates that a subset of prostate cancer driven by autocrine Wnt signaling is sensitive to Wnt synthesis inhibitors.