Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats.

Meng-Meng Liu Jiang-Zheng Liu Chen-Qian Zhao Peng Guo Zhao Wang Hao Wu Wei-Hua Yu Rui Liu Chun-Xu Hai Xiao-Di Zhang

Published in: BMC pharmacology & toxicology (2023)

PTX could ameliorate chlorine-induced lung injury via inhibition effects on oxidative stress, hypoxia and autophagy, thus suggesting that PTX could serve as a potential therapeutic approach for ALI.

Keyphrases

oxidative stress
diabetic rats
drinking water
high glucose
endothelial cells
cell death
induced apoptosis
dna damage
endoplasmic reticulum stress
ischemia reperfusion injury
signaling pathway
drug induced