Targeted and shallow whole genome sequencing identifies therapeutic opportunities in p53abn endometrial cancers.

Amy Jamieson Juliana Sobral de Barros Dawn R Cochrane J Maxwell Douglas Sameer Shankar Branden J Lynch Samuel C Y Leung Spencer D Martin Janine Senz Amy Lum Yvette Drew C Blake Gilks David G Huntsman Jessica Nell McAlpine

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

sWGS and targeted sequencing identified therapeutic opportunities in 75% of p53abn EC patients. Further research is needed to determine the efficacy of treatments targeting these identified pathways within p53abn ECs.

Keyphrases

cancer therapy
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
genome wide
single cell
dna methylation
patient reported outcomes