Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat.

Dina Mourad SalehWilliam T AlexanderTakamasa NumanoOmnia Hosny Mohamed AhmedSivagami GunasekaranDavid B AlexanderMohamed AbdelgiedAhmed M El-GazzarHiroshi TakaseJiegou XuAya Naiki-ItoSatoru TakahashiAkihiko HiroseMakoto OhnishiJun KannoHiroyuki Tsuda

Published in: Particle and fibre toxicology (2020)

The results of this initial study indicate that tangled-type MWCNT-B is carcinogenic to the rat lung when administered via the airway, and that straight-type MWCNT-A did not have higher carcinogenic potential in the rat lung than tangled-type MWCNT-B.

Keyphrases

oxidative stress
carbon nanotubes