Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu "Kadsura coccinea" Stems.
Sheng Zhuo HuangLin Ping DuanHao WangWen Li MeiHao Fu DaiPublished in: Molecules (Basel, Switzerland) (2019)
Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman's Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively.
Keyphrases
- magnetic resonance
- mass spectrometry
- high resolution
- solid state
- photodynamic therapy
- ion batteries
- liquid chromatography
- molecular docking
- high performance liquid chromatography
- gas chromatography
- ms ms
- multiple sclerosis
- electronic health record
- contrast enhanced
- capillary electrophoresis
- big data
- machine learning
- human health
- risk assessment
- climate change
- tandem mass spectrometry