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Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer.

Hatim BoughanemAmanda Cabrera-MuleroPablo Hernández-AlonsoMercedes Clemente-PostigoFelipe F CasanuevaFrancisco José TinahonesSonsoles MorcilloAna B CrujeirasManuel Macias-González
Published in: Clinical epigenetics (2020)
Our results showed that higher circulating vitamin D is associated with low SFRP2 promoter methylation. Therefore, our results could suggest that vitamin D may have an epigenetic effect on DNA methylation. Finally, higher vitamin D could contribute to an improvement response to neoadjuvant treatment.
Keyphrases
  • dna methylation
  • genome wide
  • gene expression
  • rectal cancer
  • lymph node
  • squamous cell carcinoma
  • copy number
  • locally advanced
  • transcription factor