Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer.

Hatim BoughanemAmanda Cabrera-MuleroPablo Hernández-AlonsoMercedes Clemente-PostigoFelipe F CasanuevaFrancisco José TinahonesSonsoles MorcilloAna B CrujeirasManuel Macias-González

Published in: Clinical epigenetics (2020)

Our results showed that higher circulating vitamin D is associated with low SFRP2 promoter methylation. Therefore, our results could suggest that vitamin D may have an epigenetic effect on DNA methylation. Finally, higher vitamin D could contribute to an improvement response to neoadjuvant treatment.

Keyphrases

dna methylation
genome wide
gene expression
rectal cancer
lymph node
squamous cell carcinoma
copy number
locally advanced
transcription factor