Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide-positive nerve fibres.

Suzanne M Pilkington M J Barron Rachel Elizabeth Beatrice Watson Christopher Ernest Maitland Griffiths Silvia Bulfone-Paus

Published in: The British journal of dermatology (2018)

In photoprotected skin we observed an accumulation of MCs with increasing age. These MCs have both altered functionality and distribution within the skin, which supports a role for these cells in altered tissue homeostasis during ageing.

Keyphrases

oxidative stress
induced apoptosis
soft tissue
wound healing
cell cycle arrest
cell proliferation