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Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide-positive nerve fibres.

Suzanne M PilkingtonM J BarronRachel Elizabeth Beatrice WatsonChristopher Ernest Maitland GriffithsSilvia Bulfone-Paus
Published in: The British journal of dermatology (2018)
In photoprotected skin we observed an accumulation of MCs with increasing age. These MCs have both altered functionality and distribution within the skin, which supports a role for these cells in altered tissue homeostasis during ageing.
Keyphrases
  • oxidative stress
  • induced apoptosis
  • soft tissue
  • wound healing
  • cell cycle arrest
  • cell proliferation