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Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome.

André L A NevesJiangkun YuYutaka SuzukiMarisol Baez-MaganaElena ArutyunovaEóin O'HaraTim McAllisterKim H OminskiM Joanne LemieuxLe Luo Guan
Published in: Microbiome (2021)
These findings contribute to the discovery of novel enzymes for the breakdown, biosynthesis, or modification of lignocellulose and demonstrate that the rumen microbiome is a source of promising enzyme candidates for the biotechnology industry. The combined approaches conceptualized in this study can be adapted to any microbial environment, provided that the targeted microbiome is easy to manipulate and facilitates enrichment for the microbes of interest. Video Abstract.
Keyphrases
  • small molecule
  • cancer therapy
  • high throughput
  • microbial community
  • cell wall