The role of T cell stimulated agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) in mediating multiorgan dysfunction in IL-17 induced hypertension during pregnancy.
James P HoggNathan CampbellEvangeline DeerSarah FitzgeraldDenise C CorneliusNgoc HoangTy TurnerLorena M AmaralJames P LemonTarek IbrahimBabbette B LaMarcaPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)
These findings suggest two conclusions; one is that IL-17 causes hypertension and multiorgan dysfunction in the absence of T cells and AT1-AA, possibly through its activation of innate cells and secondly, in the presence of T cells, blockade of the AT1-AA attenuates the effect of IL-17. This study indicates the critical effects of elevated IL-17 during pregnancy and suggest treatment modalities to consider for PE women.
Keyphrases
- angiotensin ii
- blood pressure
- immune response
- oxidative stress
- induced apoptosis
- systemic lupus erythematosus
- angiotensin converting enzyme
- vascular smooth muscle cells
- cell cycle arrest
- polycystic ovary syndrome
- diabetic rats
- signaling pathway
- pregnant women
- metabolic syndrome
- drug induced
- binding protein
- pregnancy outcomes
- endoplasmic reticulum stress
- arterial hypertension