Identifying genetic determinants of sarcopenia-related traits: a Mendelian randomization study of druggable genes.

Jihao WuXiong ChenRuijun LiQiying LuYucheng BaJiayun FangYilin LiuRuijie LiYixuan LiuYiling WangJinsi ChenYanbing LiYinong Huang

Published in: Metabolism: clinical and experimental (2024)

Our druggable genome-wide MR analysis identifies BORCS7, PM20D1, NUCKS1, and UQCC1 as causally associated with muscle mass and function. These findings offer insights into the genetic basis of sarcopenia, paving the way for these genes to become promising drug targets in mitigating this debilitating condition.

Keyphrases

genome wide
dna methylation
copy number
skeletal muscle
particulate matter
air pollution
magnetic resonance
community dwelling
gene expression
heavy metals
emergency department
magnetic resonance imaging
computed tomography
drug induced
transcription factor
polycyclic aromatic hydrocarbons
risk assessment