Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer.

Liwei Lang Fanghui Chen Yamin Li Chloe Shay Fan Yang Hancai Dan Zhuo G Chen Nabil F Saba Yong Teng

Published in: Cancer research communications (2023)

This work provides novel insights into c-Met-PLXDC2 signaling in radioresistance-associated aggressiveness and suggests a new mechanism-informed therapeutic strategy to overcome failure of radiotherapy in patients with HNSCC.

Keyphrases

cancer stem cells
tyrosine kinase
dna damage response
radiation therapy
radiation induced
locally advanced
dna repair