APOE and Cerebral Small Vessel Disease Markers in Patients With Intracerebral Hemorrhage.

Isabel Charlotte Hostettler David Julian SeiffgeAndrew WongGareth AmblerDuncan WilsonClare ShakeshaftGargi Banerjee Nikhil SharmaHans Rolf JägerHannah CohenTarek A YousryRustam Al-Shahi Salman Gregory Yoke Hong LipMartin M BrownKeith W Muir Henry HouldenDavid J Werring

Published in: Neurology (2022)

We confirmed associations between APOE alleles and ICH including lobar ICH. Our analysis shows selective associations between APOE ε2 and ε4 alleles with FLP, a CT marker of CAA. Our findings suggest that different APOE alleles might have diverging influences on individual neuroimaging biomarkers of CAA-associated ICH.

Keyphrases

cognitive decline
high fat diet
mild cognitive impairment
computed tomography
brain injury
subarachnoid hemorrhage
adipose tissue
insulin resistance
image quality
magnetic resonance imaging
dual energy
contrast enhanced
magnetic resonance
positron emission tomography
data analysis