Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features.

Melissa E MunroeKendra A YoungDiane L KamenJoel M GuthridgeTimothy B NiewoldKaren H CostenbaderMichael H WeismanMariko L IshimoriDaniel J WallaceGary S GilkesonDavid R KarpJohn B HarleyJill M NorrisJudith A James

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2017)

Preclinical alterations in levels of soluble mediators may predict transition to classified disease in relatives of SLE patients. Thus, immune perturbations precede SLE classification and can help identify high-risk relatives for rheumatology referral and potential enrollment in prevention trials.

Keyphrases

systemic lupus erythematosus
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
disease activity
peritoneal dialysis
machine learning
stem cells
patient reported outcomes
deep learning
bone marrow
human health