Anti-mycobacterial activity of heat and pH stable high molecular weight protein(s) secreted by a bacterial laboratory contaminant.

Md Sajid HussainAtul Vashist Mahadevan KumarNeetu Kumra TanejaUma Shankar GautamSeema DwivediJaya Sivaswami TyagiRajesh Kumar Gupta

Published in: Microbial cell factories (2022)

The present study highlights the anti-mycobacterial activity of high molecular weight protein(s) present in culture filtrate of LC-1, which may be tested further to target M. tuberculosis. The heat and pH stability of these proteins add to their characteristics as therapeutic proteins and may contribute to their long shelf life. LC-1 being a human commensal can be tested in future for its potential as a probiotic to treat tuberculosis.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
endothelial cells
heat stress
simultaneous determination
protein protein
amino acid
binding protein
mass spectrometry
current status
emergency department
small molecule
induced pluripotent stem cells
adverse drug