A Soft and Absorbable Temporary Epicardial Pacing Wire.
Chen HangLi DingShiyu ChengRuihua DongJie QiXiaoyan LiuQian LiuYan ZhangXingyu JiangPublished in: Advanced materials (Deerfield Beach, Fla.) (2021)
Existing temporary epicardial pacing wires (TPWs) are rigid and non-absorbable, such that they can cause severe complications after cardiac surgery. Here, a soft and absorbable temporary epicardial pacing wire (saTPW) for effectively correcting abnormal heart rates in a rabbit model, such as bradycardia and ventricular premature beat, is developed. The saTPW exhibits excellent conductivity, flexibility, cycling stability (>100 000 cycles), and less inflammatory response during two-month subcutaneous implantation in a rat model. The saTPW which consists of poly(l-lactide-co-ε-caprolactone) and liquid metal, can degrade about 13% (mass loss) in the rats over a two-month subcutaneous implantation. It can be absorbed over time in the body. The cytocompatibility and absorbability avoid secondary injuries caused by remaining wires which are permanently left in the body. The saTPW will provide a great platform for diagnosis and treatments in cardiovascular diseases by delivering the physiological signal and applying electrical stimulation for therapy.
Keyphrases
- cardiac resynchronization therapy
- inflammatory response
- heart failure
- left ventricular
- cardiovascular disease
- spinal cord injury
- heart rate
- early onset
- lipopolysaccharide induced
- ionic liquid
- risk factors
- toll like receptor
- lps induced
- high intensity
- atrial fibrillation
- blood pressure
- coronary artery disease
- immune response
- cardiovascular risk factors
- smoking cessation
- bone marrow
- tissue engineering
- replacement therapy