The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction.
Coenraad WithaarLaura M G MeemsGeorge Markousis-MavrogenisCornelis J BoogerdHerman H W SilljéElisabeth M SchoutenMartin M DokterCarolyn S P LamB Daan WestenbrinkCarolyn S P LamRudolf A de BoerPublished in: Cardiovascular research (2022)
We developed a mouse model that recapitulates the human HFpEF disease, providing a novel opportunity to study disease pathogenesis and the development of enhanced therapeutic approaches. We furthermore show that attenuation of cardiometabolic dysregulation may represent a novel therapeutic target for the treatment of HFpEF.