Diagnosing COVID-19: The Disease and Tools for Detection.
Buddhisha UdugamaPranav KadhiresanHannah N KozlowskiAyden MalekjahaniMatthew OsborneVanessa Y C LiHongmin ChenSamira MubarekaJonathan B GubbayWarren W C ChanPublished in: ACS nano (2020)
COVID-19 has spread globally since its discovery in Hubei province, China in December 2019. A combination of computed tomography imaging, whole genome sequencing, and electron microscopy were initially used to screen and identify SARS-CoV-2, the viral etiology of COVID-19. The aim of this review article is to inform the audience of diagnostic and surveillance technologies for SARS-CoV-2 and their performance characteristics. We describe point-of-care diagnostics that are on the horizon and encourage academics to advance their technologies beyond conception. Developing plug-and-play diagnostics to manage the SARS-CoV-2 outbreak would be useful in preventing future epidemics.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- computed tomography
- electron microscopy
- high throughput
- public health
- magnetic resonance imaging
- small molecule
- positron emission tomography
- high resolution
- south africa
- magnetic resonance
- loop mediated isothermal amplification
- mass spectrometry
- single cell
- fluorescence imaging