Titration of anti-IL-5 biologics in severe asthma: an open-label randomised controlled trial (the OPTIMAL study).
Marianne Baastrup SoendergaardAnne-Sofie BjerrumLinda Makowska RasmussenSofie Lock-JohanssonOle HilbergSusanne HansenAnna von BulowCeleste PorsbjergPublished in: The European respiratory journal (2024)
This study serves as a proof of concept for titration of anti-IL-5 biologics in patients with severe asthma with clinical control on treatment, and the OPTIMAL algorithm provides a potential framework for individualising dosing intervals in the future.