Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis.

Zuxi FengYanghuan OuXueqiang DengMinghao DengXiaohua YanLeifeng ChenFan ZhouLiang Hao

Published in: Cell & bioscience (2024)

Collectively, we demonstrated that the USP10-GSK3β-ULK1 axis promoted autophagy, cell proliferation, and invasion in OS. The findings imply that targeting USP10 may offer a promising therapeutic avenue for treating OS.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
pi k akt
oxidative stress
single cell
cell therapy
cancer therapy
drug delivery