Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease.

Paulina Gonzalez-LatapiBernabe BustosSiyuan DongSteven LubbeTanya SimuniDimitri Krainc

Published in: Annals of neurology (2024)

We provide initial evidence of alterations in DNAm in blood of PD patients that may serve as potential epigenetic biomarker of disease. To evaluate the significance of these changes throughout the progression of PD, additional profiling at longer intervals and during the prodromal stages of disease will be necessary. ANN NEUROL 2024;95:1162-1172.

Keyphrases

dna methylation
gene expression
end stage renal disease
ejection fraction
newly diagnosed
late onset