Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers.

Y A de ReusP HagedoornM G G SturkenboomFloris GrasmeijerM S BolhuisI SibumH A M KerstjensH W FrijlinkOnno W Akkerman

Published in: PloS one (2022)

Single doses of inhaled dry powder HCQ up to 20 mg are safe and well tolerated. Our data support that further studies with inhaled HCQ dry powder to evaluate pulmonary pharmacokinetics and efficacy are warranted.

Keyphrases

cystic fibrosis
pulmonary hypertension
electronic health record
open label
clinical trial
machine learning
double blind
placebo controlled