Evaluation of coagulation during treatment with directly acting antivirals in patients with hepatitis C virus related cirrhosis.
Armando TripodiRoberta D'AmbrosioLidia PadovanGiulia TosettiAlessio AghemoMassimo PrimignaniVeena ChantarangkulFlora PeyvandiMassimo ColomboPublished in: Liver international : official journal of the International Association for the Study of the Liver (2017)
Treatment with DAAs in HCV-related cirrhosis results in improvement of the individual pro- and anticoagulants. It can be hypothesised that the net effect does not substantially modify their balance (as shown by the unchanged thrombin generation in the presence of thrombomodulin) but makes it more stable and less amenable to be perturbed as presumably occurs before treatment when there is a partial deficiency for both.