Exercise training alters autoimmune cell invasion into the brain in autoimmune encephalomyelitis.
Liel HamdiHanan NabatYehuda GoldbergNina FainsteinShir SegalEfrat MediouniYarden AsisOlga TouloumiNikolaos GrigoriadisAbram KatzTamir Ben-HurOfira EinsteinPublished in: Annals of clinical and translational neurology (2022)
HICT attenuates EAE development by both immunomodulatory and neuroprotective effects. The reduction in destructive CNS inflammation in EAE is attributed to systemic inhibition of autoreactive cell migratory potential, as well as reduction in BBB permeability, which are associated with reduced VLA-4/VCAM-1 and LFA-1/ICAM-1 interactions.