Plasma ubiquitin C-terminal hydrolase-L1 (UCH-L1) level as a blood biomarker of neurological damage after allogeneic hematopoietic cell transplantation.
Yosuke OkadaHideki NakasoneKazuki YoshimuraMasaharu TamakiMachiko KusudaYuhei NakamuraMasakatsu KawamuraShunto KawamuraJunko TakeshitaNozomu YoshinoYukiko MisakiAyumi GomyoAki TaniharaShun-Ichi KimuraShinichi KakoYoshinobu KandaPublished in: International journal of hematology (2023)
Several biofluid-based biomarkers for traumatic brain injury show promise for use in diagnosis and outcome prediction. In contrast, few studies have investigated biomarkers for non-traumatic brain injury. We focused on ubiquitin C-terminal hydrolase-L1 (UCH-L1), which has been proposed as a screening tool for traumatic brain injury, and investigated whether the plasma UCH-L1 level could also be a useful biomarker in patients with non-traumatic brain injury. We measured UCH-L1 in 25 patients who had experienced neurological complications after allogeneic hematopoietic cell transplantation (HCT) and 22 control patients without any complications or graft-versus-host disease. Although UCH-L1 levels before HCT did not differ significantly (P = 0.053), levels after HCT were higher in patients with neurological complications compared with the control group (P < 0.001). At a UCH-L1 cutoff value of 0.072 ng/ml, sensitivity was 68.0% and specificity was 100%. The statistical power of UCH-L1 for neurological complications seemed to be higher than that of CT and comparable to that of MRI. Thus, increased levels of UCH-L1 might reflect the presence of neurological damage even in patients with non-traumatic brain injury. Further large cohort investigations are warranted.
Keyphrases
- traumatic brain injury
- stem cell transplantation
- severe traumatic brain injury
- end stage renal disease
- oxidative stress
- contrast enhanced
- bone marrow
- magnetic resonance imaging
- risk factors
- chronic kidney disease
- cerebral ischemia
- ejection fraction
- magnetic resonance
- small molecule
- cell cycle arrest
- atomic force microscopy
- hematopoietic stem cell
- big data
- cell death
- cell proliferation
- signaling pathway
- patient reported outcomes
- positron emission tomography
- patient reported
- single molecule
- high speed