The spinal NR2BR/ERK2 pathway as a target for the central sensitization of collagen-induced arthritis pain.
Yingming XuKui ZhangJinlin MiaoPeng ZhaoMinghua LvJia LiXianghui FuXing LuoJianli JiangPublished in: PloS one (2018)
Specific enhancement of NR2BR in the spinal dorsal horn may be vital for central sensitization in the CIA model of RA. The NR2BR/ERK2 pathway may be a promising target for pain management in RA patients.
Keyphrases
- pain management
- spinal cord
- neuropathic pain
- rheumatoid arthritis
- chronic pain
- end stage renal disease
- signaling pathway
- ejection fraction
- cell proliferation
- chronic kidney disease
- newly diagnosed
- pi k akt
- disease activity
- spinal cord injury
- ankylosing spondylitis
- diabetic rats
- patient reported outcomes
- systemic lupus erythematosus
- high glucose
- drug induced
- patient reported
- wound healing