Dissociable effects of cannabis with and without cannabidiol on the human brain's resting-state functional connectivity.
Matthew B WallRebecca PopeTom P FreemanOliwia S KowalczykLysia DemetriouClaire MokryszChandni HindochaWill LawnMichael Ap BloomfieldAbigail M FreemanAmanda FeildingDavid NuttH Valerie CurranPublished in: Journal of psychopharmacology (Oxford, England) (2019)
THC disrupts the DMN, and the PCC is a key brain region involved in the subjective experience of THC intoxication. CBD restores disruption of the salience network by THC, which may explain its potential to treat disorders of salience such as psychosis and addiction.