Blood RNA signatures outperform CRP triage of tuberculosis lymphadenitis and pericarditis.
Tiffeney MannStephanie MinniesRishi K GuptaByron Wp ReeveGeorgina NyawoZaida PalmerCharissa C NaidooAnton DoubellAlfonso PecararoThadathilankal-Jess JohnPawel SchubertClaire Jacqueline CalderwoodAneesh ChandranGrant TheronMahdad NoursadeghiPublished in: medRxiv : the preprint server for health sciences (2024)
Blood RNA biomarkers show some potential as diagnostic triage tests for TB lymphadenitis and TB pericarditis, but do not provide the level of accuracy for blood-based triage tests recommended by WHO for community-based tests. CRP has inferior diagnostic accuracy to blood RNA biomarkers and cannot be recommended for diagnostic triage among people with EPTB syndromes referred for invasive sampling.