A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis.

Eugénie KoumakisMatthieu BouazizPhilippe DieudéBarbara RuizGabriella RiemekastenPaolo AiroMartina Müller-NurasyidDaniele CusiMarco Matucci-CerinicInga MelchersErika SalviKonstantin StrauchAnnette PetersGiovanna CuomoEric HachullaElisabeth DiotNicolas HunzelmannPaola CaramaschiValeria RiccieriJörg H W DistlerIngo TarnerJérôme AvouacLuc LetenneurPhilippe AmouyelJean-Charles LambertGilles ChiocchiaCatherine BoileauYannick Allanore

Published in: Arthritis and rheumatism (2014)

The results of this study establish CCR6 as a new susceptibility factor for antitopoisomerase-positive SSc, as demonstrated in 3 European Caucasian populations, confirming the notion that SSc and RA could conceivably share autoimmune risk alleles. The results also suggest a potential role of the interleukin-17 pathway in SSc.

Keyphrases

systemic sclerosis
interstitial lung disease
dendritic cells
regulatory t cells
rheumatoid arthritis
multiple sclerosis
transcription factor
risk assessment
african american
disease activity
immune response
systemic lupus erythematosus
idiopathic pulmonary fibrosis
climate change
human health
breast cancer risk