Cobalt-Catalyzed Diastereoselective Cross-Couplings between Alkynylzinc Pivalates and Functionalized Cyclic Iodides or Bromides.

Lucie ThomasFerdinand H LutterMaximilian S HofmayerKonstantin KaraghiosoffPaul Knochel

Published in: Organic letters (2018)

Various 1,2-, 1,3-, and 1,4-substituted cyclic iodides or bromides undergo highly diastereoselective cross-couplings (diastereoselectivity (dr) up to 99:1) with a range of alkynylzinc pivalates, using CoCl2 (20 mol %) and trans- N, N, N', N'-tetramethylcyclohexane-1,2-diamine as a catalytic system.

Keyphrases

molecular docking
room temperature
editorial comment
gold nanoparticles
molecularly imprinted
carbon nanotubes
crystal structure
tandem mass spectrometry