Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists With Platelet PAR (Protease-Activated Receptor)-1 and PAR-4-Mediated Thrombin Resistance.
Sonali Rukshana GnanenthiranGabrielle J PenningsCaroline J ReddelHeather CampbellMaaike KockxJustin R HamiltonVivien M ChenLeonard KritharidesPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Aging is associated with a distinctive platelet phenotype of increased basal activation, ADP hyperreactivity, and thrombin resistance. In situ thrombin generation associated with systemic inflammation may be novel target to prevent cardiovascular disease in the elderly.