Clozapine induces astrocyte-dependent FDG-PET hypometabolism.

Andréia RochaBruna BellaverDébora G SouzaGuilherme SchuIgor C FontanaGianina T VenturinSamuel GreggioFernanda U FontellaManoela L SchiaveninLuiza S MachadoDiogo MironJaderson C da CostaPedro Rosa-NetoDiogo O SouzaLuc PellerinEduardo R Zimmer

Published in: European journal of nuclear medicine and molecular imaging (2022)

This work provides in vivo demonstration that GLT-1 downregulation induces astrocyte-dependent cortical FDG-PET hypometabolism-mimicking the hypometabolic signature seen in people developing dementia-and adds further evidence that astrocytes are key contributors of the FDG-PET signal.

Keyphrases

pet ct
positron emission tomography
pet imaging
computed tomography
mild cognitive impairment
cell proliferation
signaling pathway