The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally.

Varinia García-MolineroJosé García-MartínezRohit RejaPedro Furió-TaríOreto AntúnezVinesh VinayachandranAna ConesaB Franklin PughJosé E Pérez-OrtínSusana Rodríguez-Navarro

Published in: Epigenetics & chromatin (2018)

Our study provides support for a model in which SAGA/TREX-2 factor Sus1 acts as a global transcriptional regulator in yeast but has differential activity at yeast genes as a function of their transcription rate or during stress conditions.

Keyphrases

transcription factor
genome wide
genome wide identification
saccharomyces cerevisiae
bioinformatics analysis
gene expression
bone mineral density
dna methylation
binding protein
postmenopausal women
stress induced
protein kinase