Blunted circadian variation of blood pressure in individuals with neurofibromatosis type 1.
Ana M Cieza RiveraTania Fernández-VillaVicente MartínIsis AtallahPublished in: Orphanet journal of rare diseases (2023)
Most NF1 patients in this study showed a "non-dipper" pattern with a blunted nocturnal BP decline, which is considered an independent risk factor for cardiovascular events in normotensive and hypertensive individuals. Periodic monitoring of BP should be included in NF1 follow-up guidelines to diagnose masked hypertension or a non-dipper/riser pattern which would significantly increase the morbidity and mortality of NF1 patients to implement therapeutic strategies.
Keyphrases
- blood pressure
- end stage renal disease
- cardiovascular events
- newly diagnosed
- ejection fraction
- signaling pathway
- lps induced
- chronic kidney disease
- prognostic factors
- oxidative stress
- cardiovascular disease
- type diabetes
- metabolic syndrome
- nuclear factor
- clinical practice
- insulin resistance
- cell proliferation
- glycemic control