Unexpected severe hepatic and skin toxicities during high dose methotrexate course for osteosarcoma.

Helene SalaunLouis Romée Le NailCorinne SimonBerengere NarcisoGonzague De PinieuxHélène VegasArmelle Vinceneux

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2022)

No classical toxicities risk factors were identified in this patient but a homozygote mutation of MTHFR gene and homozygote SLCO1B1 gene mutation were found. MTHFR and SLCO1B1 are both implicated in methotrexate metabolism.

Keyphrases

high dose
risk factors
stem cell transplantation
low dose
case report
copy number
genome wide
early onset
soft tissue
wound healing
genome wide identification
gene expression
drug induced
transcription factor
genome wide analysis