Characterisation of early ultrastructural changes in the cerebral white matter of CADASIL small vessel disease using high-pressure freezing/freeze-substitution.
Rikesh M RajaniNicolas DupréValérie Domenga-DenierGuillaume Van NielXavier HeiligensteinAnne JoutelPublished in: Neuropathology and applied neurobiology (2021)
We conclude that early WM lesions in CADASIL affect first and foremost the myelin sheath and the inner tongue, suggestive of a primary myelin injury. We propose that those defects are consistent with a hypoxic/ischaemic mechanism.