Demonstration of Safety in Wild Type Mice of npFOXF1, a Novel Nanoparticle-Based Gene Therapy for Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins.

Fatemeh KohramZicheng DengYufang ZhangAbid A RezaEnhong LiOlena A KolesnichenkoSamriddhi ShuklaVladimir UstiyanJose Gomez-ArroyoAnusha AcharyaDonglu ShiVladimir V KalinichenkoAlan P Kenny

Published in: Biologics : targets & therapy (2023)

In conclusion, npFOXF1 has a very good safety profile and combined with preceding studies showing therapeutic efficacy, npFOXF1 can be considered as a good candidate therapy for ACDMPV in human neonates.

Keyphrases

wild type
endothelial cells
pulmonary hypertension
genome wide
dna methylation
copy number
type diabetes
gene expression
case control
inferior vena cava
preterm infants
insulin resistance
preterm birth