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On-Demand Release of Hydrosoluble Drugs from a Paramagnetic Porous Collagen-Based Scaffold.

Simona BettiniValentina BonfrateMarta MadaghieleLuca SalvatoreZois SyrgiannisGabriele GiancaneLudovico Valli
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)
The design of a collagen scaffold containing iron oxide nanostructures capped by a TiO2 (anatase) layer is reported. The TiO2 shell is proposed to perform a dual role: 1) as an innovative and biocompatible cross-linker agent, providing binding sites to the protein moiety, through the well-known TiO2 chemical affinity towards carboxyl groups, and 2) as a protective surface layer for the paramagnetic core against oxidation. Simultaneously, the presence of the nanostructures confers to the collagen gel sensitivity to an external stimulus; that is, the application of a magnetic field. The hybrid biomaterial was demonstrated to be nontoxic and is proposed as a smart scaffold for the release of bioactive compounds on demand. The tuneable release of a model protein (myoglobin) upon application of a magnetic field was investigated. Myoglobin was loaded in the microporous material and discharge was induced by consecutive magnet applications, leading to release of the protein with high spatio-temporal and dosage control.
Keyphrases
  • tissue engineering
  • wound healing
  • protein protein
  • quantum dots
  • visible light
  • amino acid
  • iron oxide
  • drug delivery
  • hydrogen peroxide
  • small molecule
  • high resolution
  • metal organic framework
  • hyaluronic acid