Synthesis of Isotopic Atropisomers Based on 12 C/ 13 C Discrimination.

Ryunosuke SendaYuka WatanabeShota MiwaAzusa SatoOsamu Kitagawa

Published in: The Journal of organic chemistry (2023)

Quinazolin-4-one derivatives possessing an isotopic atropisomerism (isotopic N-C axial chirality) based on ortho - 12 CH 3 / 13 CH 3 discrimination were prepared. The diastereomeric quinazolin-4-ones bearing an asymmetric carbon as well as an isotopic atropisomerism were clearly discriminated by 1 H and 13 C NMR spectra and revealed to possess high rotational stability and stereochemical purity.

Keyphrases

room temperature
magnetic resonance
solid state
high resolution
density functional theory
mass spectrometry
molecular dynamics