Evaluation of Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Glomerular Filtration Rate and Amikacin Clearance During Early Rat Endotoxemia: Comparison with Traditional Endogenous and Exogenous Biomarkers.
Šárka StudenáEva DoleželováJolana CermanováAlena PrašnickáDrahomíra SpringerStanislav MičudaJaroslav ChládekPublished in: European journal of drug metabolism and pharmacokinetics (2020)
During early endotoxemia in the rat, pNGAL has a moderate predictive ability towards CLam. Clinical studies should verify whether pNGAL can support individualized dosing of aminoglycosides to septic patients.