Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer.
Yi-Hsiu ChungKuan-Ying LuShao-Chieh ChiuChi-Jen LoLi-Man HungJiung-Pang HuangMei-Ling ChengChao-Hung WangCheng-Kun TsaiYu-Chun LinShang-Hung ChangGigin LinPublished in: Contrast media & molecular imaging (2018)
HFD-induced IR associated with increased glucose utility undergoing oxidative phosphorylation via the TCA cycle in the myocardium is supported by overexpression of glucose transporter, acetyl-CoA synthase. Noninvasive imaging biomarker has potentials in detecting the metabolic perturbations prior to the decline of the left ventricular function.
Keyphrases
- insulin resistance
- high fat diet induced
- left ventricular
- magnetic resonance
- blood glucose
- positron emission tomography
- high resolution
- high fat diet
- pet imaging
- pet ct
- type diabetes
- metabolic syndrome
- heart failure
- cell proliferation
- acute myocardial infarction
- skeletal muscle
- magnetic resonance imaging
- high glucose
- oxidative stress
- blood pressure
- aortic valve
- photodynamic therapy
- endothelial cells
- protein kinase