High-Dimensional and Spatial Analysis Reveals Immune Landscape-Dependent Progression in Cutaneous Squamous Cell Carcinoma.
Angela L FergusonAshleigh R SharmanRuth O AllenThomas YeJenny H J LeeTsu-Hui Hubert LowSydney Ch'ngCarsten E PalmeBruce G AshfordMarie RansonJonathan Robert ClarkEllis PatrickRuta GuptaUmaimainthan PalendiraPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Effective responses from both CD8+ and CD4+ T cells in the tumor microenvironment are essential for immune control of primary HNcSCC. Our findings indicate that the early events that shape the immune responses in primary tumors dictate progression and disease outcomes in HNcSCC.