Effect of age on metabolomic changes in a model of paclitaxel-induced peripheral neurotoxicity.

Roberta Bonomo Annalisa Canta Alessia Chiorazzi Valentina Alda Carozzi Cristina Meregalli Eleonora Pozzi Paola AlbertiCecile F FrampasDaan R van der Veen Paola Marmiroli Debra Jean Skene Guido Cavaletti

Published in: Journal of the peripheral nervous system : JPNS (2023)

Our study identifies for the first time multiple related metabolic axes involved in PTX-induced peripheral neurotoxicity, and suggests age-related differences in CIPN manifestations and in the metabolic profile.

Keyphrases

chemotherapy induced
high glucose
diabetic rats
drug induced
oxidative stress
endothelial cells
gene expression