Login / Signup

ARID1A mutation and genomic stability.

Timothy NacarelliBo ZhaoXue HaoRugang Zhang
Published in: Molecular & cellular oncology (2020)
We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated cancers. These findings explain the long-standing paradox between mitotic defects caused by ARID1A inactivation and the lack of genomic instability in ARID1A-mutated cancers.
Keyphrases
  • copy number
  • cell cycle
  • bone marrow
  • young adults
  • genome wide
  • children with cerebral palsy