Actionable Genotypes and Their Association with Life Span in Iceland.
Brynjar Orn JenssonGudny A ArnadottirHildigunnur KatrinardottirRun FridriksdottirHannes HelgasonAsmundur OddssonGardar SveinbjornssonHannes P EggertssonGisli H HalldorssonBjarni A AtlasonHakon JonssonGudjon R OskarssonArni SturlusonSigurjon A GudjonssonGudmundur A ThorissonFlorian ZinkKristjan Helgi Swerford MooreGunnar PalssonAsgeir SigurdssonAdalbjorg JonasdottirAslaug JonasdottirOlafur T MagnussonAnna HelgadottirValgerdur SteinthorsdottirJulius GudmundssonSimon N StaceyRafn HilmarssonIsleifur OlafssonOskar T JohannssonDavid O ArnarJona SaemundsdottirOlafur T MagnussonGisli MassonBjarni V HalldorssonAgnar HelgasonHreinn StefanssonIngileif JonsdottirHilma HolmThorunn RafnarUnnur ThorsteinsdottirDaniel F GudbjartssonKari StefanssonPatrick SulemPublished in: The New England journal of medicine (2023)
On the basis of the ACMG SF v3.0 guidelines, we found that approximately 1 in 25 Icelanders carried an actionable genotype and that carrying such a genotype was associated with a reduced life span. (Funded by deCODE Genetics-Amgen.).
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